MyBioSource.com's TR10A Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The TR10A Antibody was generated using CD261, TNFRSF10A, and TRAILR1 as the antigen and it reacts with Human, and Mouse.
Description
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Pan G., Science 276:111-113(1997).The MGC Project Team, Genome Res. 14:2121-2127(2004).Chaudhary P.M., Immunity 7:821-830(1997)